{"id":2523,"date":"2023-06-23T15:30:19","date_gmt":"2023-06-23T15:30:19","guid":{"rendered":"https:\/\/ciehaufr1i.wpdns.site\/nouvelles\/decouvrez-comment-bayer-peut-ameliorer-vos-pratiques-chirurgicales-et-dimagerie\/"},"modified":"2024-08-30T14:27:51","modified_gmt":"2024-08-30T14:27:51","slug":"decouvrez-comment-bayer-peut-ameliorer-vos-pratiques-chirurgicales-et-dimagerie","status":"publish","type":"post","link":"https:\/\/car.ca\/fr\/nouvelles\/decouvrez-comment-bayer-peut-ameliorer-vos-pratiques-chirurgicales-et-dimagerie\/","title":{"rendered":"D\u00e9couvrez comment Bayer peut am\u00e9liorer vos pratiques chirurgicales et d\u2019imagerie"},"content":{"rendered":"

L\u2019examen d\u2019imagerie par r\u00e9sonance magn\u00e9tique (IRM) avec injection de Primovist joue un r\u00f4le bien \u00e9tabli dans la d\u00e9tection des m\u00e9tastases h\u00e9patiques chez les patients atteints de cancer colorectal\u00a0: il favorise la d\u00e9tection des l\u00e9sions (en particulier des l\u00e9sions \u2264\u00a01,0\u00a0cm), r\u00e9duit le recours \u00e0 des examens d\u2019imagerie suppl\u00e9mentaires, limite les modifications du plan chirurgical en cours d\u2019intervention et augmente la confiance dans le diagnostic par rapport \u00e0 la tomodensitom\u00e9trie (TDM) avec produit de contraste.<\/p>\n

\"\"Des recherches r\u00e9centes ont mis en \u00e9vidence le r\u00f4le grandissant de Primovist chez les patients pr\u00e9sentant un ad\u00e9nocarcinome canalaire pancr\u00e9atique. La r\u00e9section chirurgicale est souvent le seul traitement curatif pour ce cancer mortel, mais la pr\u00e9sence de m\u00e9tastases h\u00e9patiques emp\u00eache les patients d\u2019en b\u00e9n\u00e9ficier.<\/p>\n

La TDM avec produit de contraste est couramment utilis\u00e9e pour d\u00e9terminer le stade de l\u2019ad\u00e9nocarcinome canalaire pancr\u00e9atique et pour d\u00e9tecter des m\u00e9tastases. Toutefois, jusqu\u2019\u00e0 41\u00a0% des patients jug\u00e9s candidats \u00e0 la r\u00e9section, d\u2019apr\u00e8s la TDM, subissent une laparotomie inutile (non th\u00e9rapeutique). Cela s\u2019explique par la d\u00e9tection fortuite de m\u00e9tastases h\u00e9patiques durant l\u2019intervention, entra\u00eenant l\u2019impossibilit\u00e9 de proc\u00e9der \u00e0 une r\u00e9section curative. La chirurgie \u00e9tant associ\u00e9e \u00e0 un risque de morbidit\u00e9 et de mortalit\u00e9, \u00e0 un retard d\u2019instauration de traitements de rechange, \u00e0 une augmentation des co\u00fbts de soins de sant\u00e9 et \u00e0 des r\u00e9percussions potentielles sur la sant\u00e9 mentale, la d\u00e9tection pr\u00e9op\u00e9ratoire des m\u00e9tastases h\u00e9patiques est essentielle.<\/p>\n

Une \u00e9tude canadienne du R\u00e9seau universitaire de sant\u00e9 de Toronto visait \u00e0 examiner l\u2019efficacit\u00e9 de l\u2019IRM avec injection de Primovist par rapport \u00e0 la TDM avec produit de contraste dans le diagnostic des l\u00e9sions et la planification chirurgicale chez 66 patients. L\u2019analyse comparative des deux modalit\u00e9s reposait sur les rapports cliniques et radiologiques, et sur l\u2019analyse r\u00e9trospective et \u00e0 l\u2019insu de clich\u00e9s par deux radiologistes sp\u00e9cialistes de l\u2019abdomen avec, comme r\u00e9f\u00e9rences, les r\u00e9sultats des analyses histopathologiques et les observations intraop\u00e9ratoires et\/ou lors du suivi.<\/p>\n

Dans l\u2019ensemble, l\u2019IRM avec injection de Primovist a montr\u00e9 une sensibilit\u00e9 sup\u00e9rieure (71,7\u00a0% par rapport \u00e0 34\u00a0%, p<\/em>\u00a0=\u00a00,009) avec une sp\u00e9cificit\u00e9 comparable (98,6\u00a0% par rapport \u00e0 100\u00a0%). La d\u00e9tection plus efficace des l\u00e9sions gr\u00e2ce \u00e0 Primovist a permis d\u2019exclure la chirurgie chez 7,6\u00a0% patients de plus qu\u2019avec la TDM avec produit de contraste, et pourrait permettre d\u2019\u00e9viter jusqu\u2019\u00e0 13,6\u00a0% des \u00e9checs d\u2019interventions chirurgicales \u00e0 des fins curatives. Comme pour les m\u00e9tastases h\u00e9patiques chez les patients atteints d\u2019un cancer colorectal, l\u2019IRM avec injection de Primovist a permis de d\u00e9tecter un plus grand nombre de l\u00e9sions de petite taille (\u2264\u00a01,0\u00a0cm) et un moins grand nombre de l\u00e9sions jug\u00e9es \u00ab\u00a0ind\u00e9termin\u00e9es\u00a0\u00bb, par rapport \u00e0 la TDM avec produit de contraste.<\/p>\n

L\u2019importance de Primovist dans la d\u00e9tection de m\u00e9tastases h\u00e9patiques chez les patients atteints d\u2019un cancer du pancr\u00e9as a \u00e9galement \u00e9t\u00e9 montr\u00e9 dans d\u2019autres publications et pourrait permettre de pr\u00e9dire le pronostic. Dans l\u2019ensemble, les recherches ont d\u00e9montr\u00e9 que Primovist pourrait jouer un r\u00f4le croissant dans cette population de patients, accro\u00eetre la probabilit\u00e9 de choisir la r\u00e9section chirurgicale chez les patients appropri\u00e9s et limiter le nombre d\u2019interventions chirurgicales inutiles.<\/p>\n

D\u00e9couvrez comment Bayer peut am\u00e9liorer vos pratiques chirurgicales et d\u2019imagerie<\/a>.<\/strong><\/p>\n

R\u00e9f\u00e9rences\u00a0:<\/h5>\n
    \n
  1. Zech, C. J., Korpraphong, P., Huppertz, A., Denecke, T., Kim, M. J., Tanomkiat, W., … & Ba-Ssalamah, A. (2014). Randomized multicentre trial of gadoxetic acid-enhanced MRI versus conventional MRI or CT in the staging of colorectal cancer liver metastases.\u00a0Journal of British Surgery<\/em>,\u00a0101<\/em>(6), 613-621.<\/li>\n
  2. Jhaveri, K. S., Babaei Jandaghi, A., Thipphavong, S., Espin-Garcia, O., Dodd, A., Hutchinson, S., … & Gallinger, S. (2021). Can preoperative liver MRI with gadoxetic acid help reduce open-close laparotomies for curative intent pancreatic cancer surgery?\u00a0Cancer Imaging<\/em>,\u00a021<\/em>(1), 45.<\/li>\n
  3. Noda, Y., Goshima, S., Takai, Y., Kawai, N., Kawada, H., Tanahashi, Y., & Matsuo, M. (2020). Detection of pancreatic ductal adenocarcinoma and liver metastases: comparison of Gd-EOB-DTPA-enhanced MR imaging vs. extracellular contrast materials.\u00a0Abdominal radiology<\/em>,\u00a045<\/em>, 2459-2468.<\/li>\n
  4. Ito, T., Sugiura, T., Okamura, Y., Yamamoto, Y., Ashida, R., Aramaki, T., … & Uesaka, K. (2017). The diagnostic advantage of EOB-MR imaging over CT in the detection of liver metastasis in patients with potentially resectable pancreatic cancer.\u00a0Pancreatology<\/em>,\u00a017<\/em>(3), 451-456.<\/li>\n
  5. Noda, Y., Tochigi, T., Baliyan, V., Kordbacheh, H., & Kambadakone, A. (2021). Hepatobiliary contrast uptake patterns on gadoxetic acid\u2013enhanced MRI in liver metastases from pancreatic ductal adenocarcinoma: can it predict prognosis?\u00a0European Radiology<\/em>,\u00a031<\/em>, 276-282.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    L\u2019examen d\u2019imagerie par r\u00e9sonance magn\u00e9tique (IRM) avec injection de Primovist joue un r\u00f4le bien \u00e9tabli dans la d\u00e9tection des m\u00e9tastases h\u00e9patiques chez les patients atteints de cancer colorectal\u00a0: il favorise la d\u00e9tection des l\u00e9sions (en particulier des l\u00e9sions \u2264\u00a01,0\u00a0cm), r\u00e9duit le recours \u00e0 des examens d\u2019imagerie suppl\u00e9mentaires, limite les modifications du plan chirurgical en cours […]<\/p>\n","protected":false},"author":2,"featured_media":1474,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_searchwp_excluded":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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Jones","author_link":"https:\/\/car.ca\/fr\/author\/tenika\/"},"uagb_comment_info":0,"uagb_excerpt":"L\u2019examen d\u2019imagerie par r\u00e9sonance magn\u00e9tique (IRM) avec injection de Primovist joue un r\u00f4le bien \u00e9tabli dans la d\u00e9tection des m\u00e9tastases h\u00e9patiques chez les patients atteints de cancer colorectal\u00a0: il favorise la d\u00e9tection des l\u00e9sions (en particulier des l\u00e9sions \u2264\u00a01,0\u00a0cm), r\u00e9duit le recours \u00e0 des examens d\u2019imagerie suppl\u00e9mentaires, limite les modifications du plan chirurgical en cours\u2026","_links":{"self":[{"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/posts\/2523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/comments?post=2523"}],"version-history":[{"count":3,"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/posts\/2523\/revisions"}],"predecessor-version":[{"id":2881,"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/posts\/2523\/revisions\/2881"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/media\/1474"}],"wp:attachment":[{"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/media?parent=2523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/categories?post=2523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/tags?post=2523"},{"taxonomy":"post_topic_taxonomy","embeddable":true,"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/post_topic_taxonomy?post=2523"},{"taxonomy":"post_modality_taxonomy","embeddable":true,"href":"https:\/\/car.ca\/fr\/wp-json\/wp\/v2\/post_modality_taxonomy?post=2523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}